The COVID-19 pandemic has raised salient questions about global intellectual property rights rules and their implementation at regional, sub-regional and national levels. These questions revolve around the tensions between private rights and the public interest. For example, how can governments employ flexibilities and other measures to facilitate access to pharmaceutical products including drugs, vaccines, test kits, personal protective equipment and related technologies? Or how can governments navigate the intersections of copyright and the right to education to promote access to educational materials for teaching and learning? Broader conceptual, practical, and institutional issues, foregrounded on fostering development-oriented intellectual property rights systems in the Global South, will be analysed from different perspectives.